Successful treatment of systemic cryptococcosis with miconazole.

Neonatal systemic candidiasis treated with miconazole.

Cryptococcosis: long-lasting presence of fungi after successful treatment.

Sir, Cryptococcosis is an opportunistic infection caused by Cryptococcus neoformans and is usually seen in immunocompromised patients. Histopathologically, the skin lesions are divided into two types, i.e. cystic and granulomatous lesions (1, 2), each of which occurs exclusively depending on the conditions of individual hosts (3). For unknown reason the titre of cryptococcal antigen in patients...

Treatment of experimental murine cryptococcosis: a comparison of miconazole and amphotericin B.

Miconazole was compared with amphotericin B in the treatment of murine cryptococcosis. Both subcutaneous and intraperitoneal administration of miconazole produced serum levels higher than the minimum inhibitory concentration for the challenge strain. However, maximal tolerable doses of miconazole gave no increase in survival. When combined with amphotericin B, miconazole demonstrated neither ad...

Successful treatment of gangrene in systemic necrotizing vasculitis with iloprost.

Systemic necrotizing vasculitis is uncommon in children and may be rarely associated with gangrene. We describe a 3-yr-old girl with parvovirus B19-induced necrotizing vasculitis whose digital gangrene was successfully treated with iloprost, a prostacyclin analogue.

Phenytoin intoxication during treatment with parenteral miconazole.

We describe a patient in whom phenytoin toxicity developed soon after treatment with parenteral miconazole. A 51 year old man was admitted for treatment of recurrent severe haemoptysis associated with pulmonary aspergillosis. He was in chronic respiratory failure. He was a non-smoker. Biochemical 'indices of liver function were normal. There was a past history of asthma and also of epilepsy for...